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Oc, I agree. However, like
Oc, I agree. However, like Disavowed I try to keep my PC as clean as possible to prolong the eventual wipe and reinstall. Right before my recent wipe I tried a new tool that you get for free by downloading it as part of the Google Pack (beta). I think it was called PC Doctor...? I found it way too resource intensive. Had to uninstall. I eventually went back to Spybot S&D and Adaware, which I've been using for years. I also added AVG anti-spyware and AVG anti-rootkit to give them a whirl.
Spybot and Adaware have been the core of my defense for quite a while. I started using AVG for anti-virus about a year ago, but it's never found a single thing (not that its inept, but I don't think viruses are a big problem for me).
I'd say those tools will keep you clean for as long as you can reasonably expect anything to keep you clean.